| Expression pattern: |
UP |
| Associated gene: |
WDR5 / WD repeat domain 5 / WDR5 mRNA |
| Associated microRNA: |
miR-29a |
| Biological function: |
Promotes cervical cancer cell proliferation and invasion, inhibits apoptosis, and promotes tumour growth in vivo. |
| Molecular mechanism: |
circ_0072995 drives cervical cancer development by sponging miR-29a and inducing WDR5 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Luciferase Reporter Assay; IF (Immunofluorescence); Transwell Assay; Annexin V/PI Flow Cytometry; IHC (Immunohistochemistry); Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ_0072995 expression was correlated with histological types and FIGO staging, with the highest level observed in cervical squamous carcinoma and advanced stages; circ_0072995 may serve as a therapeutic target for cervical cancer. |
| Description: |
circ_0072995 is up-regulated in cervical cancer tissues and is associated with histological type and FIGO stage. Functionally, it promotes cervical cancer cell proliferation and invasion, inhibits apoptosis, and supports tumour growth in vivo. Mechanistically, circ_0072995 acts through the miR-29a/WDR5 axis, suggesting potential therapeutic relevance. |
| Confidence score: |
0.7369 |