circRNA basic information
circBase ID: -
Name: hsa_circ_USP48
Synonym: circ6
Host Gene: USP48
Genomic location(hg19): chr6:80489161-80496941:-
Genomic location(hg38): chr6:79779444-79787224:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005765
MONDO name: foot and mouth disease
Disease details: foot-and-mouth disease / FMD
Disease DO ID:
 -
Disease MeSH ID:
 D005536
Disease NCIt ID:
 -
Disease ICD11 ID:
 1008730501
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

PK-15 cells
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: FMDV Lpro
Associated microRNA: -
Biological function: associated with ubiquitination processing and potentially involved in immune escape
Molecular mechanism: Not specified
Biological pathway or process:

ubiquitination (other); immune regulation (unclear)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; divergent primers PCR
Clinical significance:

-
Description:

circ6:79779444-79787224 (host gene USP48) is down-regulated after FMDV infection in PK-15 cells. The paper links it to ubiquitin processing and speculates it may relate to FMDV Lpro-mediated immune escape, without direct mechanistic experiments.
Confidence score:

0.437
Other information
Title:

Profiling and functional analysis of differentially expressed circular RNAs identified in foot-and-mouth disease virus infected PK-15 cells.

Journal: Veterinary research
Published: 2022
PubMed ID: 35313983
Study type:

biological research
Data availability: -
Code availability: -