circRNA basic information
circBase ID: hsa_circ_0007144
Name: hsa_circ_PTPRM
Synonym: circPTPRM
Host Gene: PTPRM
Genomic location(hg19): chr18:8076452-8143777:+
Genomic location(hg38): chr18:8076454-8143779:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer / PTC
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; paracancerous normal tissues
Cell lines:

Nthy-ori 3-1; TPC-1; KAT-5
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: DNMT3A
Associated microRNA: miR-885-5p
Biological function: promotes proliferation, migration, invasion and EMT; inhibits apoptosis in PTC cells
Molecular mechanism: ceRNA mechanism: circPTPRM sponges miR-885-5p to increase DNMT3A expression, promoting PTC progression and EMT
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High circPTPRM expression predicted poor prognosis (poor overall survival) in PTC patients
Description:

circPTPRM is up-regulated in papillary thyroid cancer and its high expression is associated with poor overall survival. Functionally, circPTPRM promotes PTC cell proliferation, migration, invasion and EMT while suppressing apoptosis, mainly by sponging miR-885-5p to upregulate DNMT3A (circPTPRM/miR-885-5p/DNMT3A axis).
Confidence score:

0.8169
Other information
Title:

CircPTPRM accelerates malignancy of papillary thyroid cancer via miR-885-5p/DNMT3A axis.

Journal: Journal of clinical laboratory analysis
Published: 2022
PubMed ID: 36098040
Study type:

combined biological and clinical study
Data availability: All data generated or analyzed during this study are included in this published article.
Code availability: -