| Expression pattern: |
UP |
| Associated gene: |
RUNX2 |
| Associated microRNA: |
miR-326 |
| Biological function: |
promotes HCC cell proliferation and cisplatin-resistance |
| Molecular mechanism: |
Acts as a ceRNA to sponge miR-326, relieving miR-326-mediated suppression of RUNX2 and thereby promoting cisplatin resistance. |
| Biological pathway or process: |
proliferation (promotes); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Luciferase Reporter Assay; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
HCC patients with high circRNA_102272 expression had lower survival rates. |
| Description: |
circRNA_102272 is up-regulated in HCC and is associated with worse patient survival. It promotes HCC cell proliferation and cisplatin resistance by acting as a ceRNA that sponges miR-326, thereby increasing RUNX2 expression. |
| Confidence score: |
0.7325 |