| Expression pattern: |
DN |
| Associated gene: |
VASH1 |
| Associated microRNA: |
miR-1269a |
| Biological function: |
Inhibits colorectal cancer cell proliferation, invasion and migration; promotes apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-1269a to regulate VASH1. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; TUNEL; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
- |
| Description: |
circASS1 is down-regulated in colorectal cancer tissues and CRC cell lines. circASS1 overexpression suppresses CRC cell proliferation, migration and invasion and promotes apoptosis by sponging miR-1269a and relieving repression of VASH1 (circASS1/miR-1269a/VASH1 axis). |
| Confidence score: |
0.6285 |