circRNA basic information
circBase ID: hsa_circ_0018289
Name: hsa_circ_SYT15
Synonym: circSYT15_003
Host Gene: SYT15
Genomic location(hg19): chr10:46968580-46969453:-
Genomic location(hg38): chr10:46580164-46581035:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer / CC
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

CC tissues; paired normal tissues; xenograft tumors
Cell lines:

HcerEpic; HeLa; SiHa
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: ICMT
Associated microRNA: miR-1294
Biological function: promotes proliferation, migration, invasion, glycolysis, and tumor growth in cervical cancer
Molecular mechanism: ceRNA mechanism: hsa_circ_0018289 sponges miR-1294 to relieve repression of ICMT
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; EdU Staining; Colony Formation Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

-
Description:

hsa_circ_0018289 is up-regulated in cervical cancer tissues/cells and promotes malignant phenotypes including proliferation, migration/invasion, glycolysis, and tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-1294 to increase ICMT expression, forming a hsa_circ_0018289/miR-1294/ICMT axis.
Confidence score:

0.8034
Other information
Title:

CircRNA hsa_circ_0018289 exerts an oncogenic role in cervical cancer progression through miR-1294/ICMT axis.

Journal: Journal of clinical laboratory analysis
Published: 2022
PubMed ID: 35312113
Study type:

combined biological and clinical study
Data availability: The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -