| Expression pattern: |
DN |
| Associated gene: |
CDKN1A, MAP2K2, GADD45A, KLF2, NR3C1, PJA2, G6PC, PPP1CB |
| Associated microRNA: |
hsa-miR-323a-3p, hsa-miR-331-5p, hsa-miR-377, hsa-miR-485-3p, hsa-miR-889, hsa-miR-370 |
| Biological function: |
Potential regulator and plasma biomarker for gastric cancer; predicted to participate in gastric cancer pathogenesis through a circRNA-miRNA-hub gene ceRNA network. |
| Molecular mechanism: |
Predicted ceRNA mechanism in which the circRNA may sponge miRNAs and regulate hub mRNAs involved in gastric cancer-related processes. |
| Biological pathway or process: |
ceRNA regulation (other); cell cycle (other); apoptosis (other); immune regulation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Potential novel plasma circRNA biomarker for gastric cancer. |
| Description: |
hsa_circ_0001190 was identified as downregulated in both gastric cancer tissue and plasma and was confirmed as lower in MGC-803 gastric cancer cells than in GES-1 cells. The study proposes it as a potential plasma biomarker and predicted ceRNA regulator in gastric cancer through miRNA-hub gene networks. |
| Confidence score: |
0.4032 |