| Expression pattern: |
UP |
| Associated gene: |
YES1 |
| Associated microRNA: |
miR-129-2-3p |
| Biological function: |
promotes doxorubicin resistance and malignant phenotypes (proliferation, migration, invasion) and inhibits apoptosis in gastric cancer |
| Molecular mechanism: |
ceRNA mechanism: circ_0081143 sponges miR-129-2-3p to increase YES1 expression |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model |
| Clinical significance: |
circ_0081143 is a promising/prospective target for treatment of GC with doxorubicin resistance |
| Description: |
circ_0081143 (from COL1A2) is up-regulated in gastric cancer, especially doxorubicin-resistant tumors and cells, and promotes malignant behaviors and doxorubicin resistance. Mechanistically, it sponges miR-129-2-3p to derepress YES1 (miR-129-2-3p/YES1 axis). Inhibiting circ_0081143 sensitizes cells to doxorubicin and suppresses xenograft tumor growth. |
| Confidence score: |
0.6825 |