circRNA basic information
circBase ID: hsa_circ_0006089
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr2:9490936-9499018:+
Genomic location(hg38): chr2:9350807-9358889:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissue; adjacent normal mucosa; serum
Cell lines:

AGS
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: EIF4A3
Associated microRNA: -
Biological function: Serum biomarker panel component for GC detection (liquid biopsy).
Molecular mechanism: Not experimentally defined; discussed potential association with RNA binding protein EIF4A3 for most panel members.
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Part of the final 8-circRNA serum model that distinguishes GC from non-disease controls (validated in an independent cohort).
Description:

hsa_circ_0006089 is included in the validated 8-circRNA liquid-biopsy panel for diagnosing gastric cancer. Its expression is quantified by RT-qPCR in tissue/serum cohorts and contributes to a multivariate risk model for GC detection.
Confidence score:

0.6556
Other information
Title:

Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer.

Journal: Molecular cancer
Published: 2022
PubMed ID: 35139874
Study type:

combined biological and clinical study
Data availability: GSE89143; GSE83521
Code availability: -