circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: circular RNA-ITCH / ITCH
Host Gene: ITCH
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008170
MONDO name: ovarian cancer
Disease details: ovarian cancer / OC
Disease DO ID:
 2394
Disease MeSH ID:
 D010051
Disease NCIt ID:
 C7431
Disease ICD11 ID:
 685124533
Disease OMIM ID:
 167000
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; adjacent healthy tissue
Cell lines:

UWB1.289 + BRCA1; UWB1.289
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: HULC
Associated microRNA: -
Biological function: Inhibits ovarian carcinoma cell proliferation; does not significantly affect cancer cell invasion and migration.
Molecular mechanism: Circular RNA-ITCH downregulates lncRNA HULC, and HULC overexpression attenuates the inhibitory effect of circular RNA-ITCH on cell proliferation.
Biological pathway or process:

proliferation (inhibits); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Sanger Sequencing; Clinical Sample Validation; Transfection; CCK8; Transwell Assay
Clinical significance:

ITCH expression was not significantly correlated with clinical stages, histological subtypes, age, and gender.
Description:

Circular RNA-ITCH is downregulated in ovarian carcinoma tissues. Its overexpression inhibits ovarian carcinoma cell proliferation, at least partly by downregulating the lncRNA HULC, while it does not significantly affect migration or invasion in the tested cell lines.
Confidence score:

0.6099
Other information
Title:

Circular RNA-ITCH Inhibits the Proliferation of Ovarian Carcinoma by Downregulating lncRNA HULC.

Journal: Reproductive sciences (Thousand Oaks, Calif.)
Published: 2020
PubMed ID: 32046413
Study type:

combined biological and clinical study
Data availability: -
Code availability: -