| Expression pattern: |
DN |
| Associated gene: |
p-ERK1/2, NF-kappaB/p65, Bcl-2, Bax, caspase-3, LC3-Ⅰ, LC3-Ⅱ, p62 |
| Associated microRNA: |
miR-139-5p |
| Biological function: |
Circular RNA EIF3K is down-regulated in inflammatory salpingitis cells, suppresses cell viability/proliferation, promotes apoptosis and autophagy, and suppresses inflammatory cell progression. |
| Molecular mechanism: |
circEIF3K sponges miR-139-5p and inhibits MAPK/NF-kappaB signaling, leading to reduced proliferation and increased apoptosis and autophagy in inflammatory salpingitis cells. |
| Biological pathway or process: |
MAPK (inhibits); NF-kappaB (inhibits); apoptosis (promotes); autophagy (promotes); proliferation (inhibits); ceRNA regulation (other); inflammation (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; CCK8; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection |
| Clinical significance: |
EIF3K could be a potential biomarker for treating salpingitis in future researches. |
| Description: |
Circular RNA EIF3K is down-regulated in Neisseria gonorrhoeae-induced inflammatory tubal epithelial cells. In this study, overexpressed circEIF3K inhibited cell viability/proliferation and promoted apoptosis and autophagy, likely by sponging miR-139-5p and suppressing MAPK/NF-kappaB signaling. The authors propose EIF3K as a potential biomarker or therapeutic factor for salpingitis research. |
| Confidence score: |
0.5416 |