| Expression pattern: |
UP |
| Associated gene: |
CKAP5 |
| Associated microRNA: |
miR-320c |
| Biological function: |
promotes proliferation, invasion, migration and EMT; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: circPDSS1 sponges miR-320c to regulate CKAP5 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; TUNEL; Transwell Assay; Wound Healing Assay; IF (Immunofluorescence); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circPDSS1 is up-regulated in breast cancer cell lines and acts as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes proliferation, invasion, migration, and EMT (and inhibits apoptosis) via a ceRNA mechanism by sponging miR-320c to upregulate CKAP5. |
| Confidence score: |
0.7923 |