circRNA basic information
circBase ID: hsa_circ_0006916
Name: hsa_circ_HOMER1
Synonym: circ-HOMER1 / circular-HOMER1
Host Gene: HOMER1
Genomic location(hg19): chr5:78734832-78752841:-
Genomic location(hg38): chr5:79439009-79457018:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tumor tissues; adjacent normal tissues
Cell lines:

Sk-Hep-1; SMMC7721; HCCLM3; Huh-7; HepG2; L02
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CXCL6
Associated microRNA: miR-1322
Biological function: Promotes HCC cell proliferation, growth, migration, invasion and aggressiveness, and inhibits apoptosis.
Molecular mechanism: circ-HOMER1 acts as a miRNA sponge for miR-1322, reduces miR-1322 activity, and increases CXCL6 expression to promote HCC growth and aggressiveness.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Cohort Study; Survival Analysis
Clinical significance:

High circ-HOMER1 expression is associated with larger tumor size, higher TNM stage, poorer overall survival, and may serve as an independent risk prognostic indicator and potential therapeutic target in HCC.
Description:

circ-HOMER1 is up-regulated in HCC tissues and cell lines and is associated with larger tumor size, advanced TNM stage, and poorer overall survival. Functionally, it promotes HCC cell proliferation, migration, invasion and aggressiveness while suppressing apoptosis. Mechanistically, cytoplasmic circ-HOMER1 sponges miR-1322 to increase CXCL6 expression, forming a circ-HOMER1/miR-1322/CXCL6 regulatory axis.
Confidence score:

0.7628
Other information
Title:

Circ-HOMER1 enhances the inhibition of miR-1322 on CXCL6 to regulate the growth and aggressiveness of hepatocellular carcinoma cells.

Journal: Journal of cellular biochemistry
Published: 2020
PubMed ID: 32037619
Study type:

combined biological and clinical study
Data availability: The datasets used in this study are available from the corresponding author.
Code availability: -