| Expression pattern: |
DN |
| Associated gene: |
FoxP3, FoxP3 mRNA |
| Associated microRNA: |
miR-1205 |
| Biological function: |
Downregulation of circETS1 promotes SLE activity and inhibits Treg cell differentiation; circETS1 overexpression promotes CD4 + T cell differentiation into Treg cells and affects the Th17/Treg ratio. |
| Molecular mechanism: |
circETS1 participates in a ceRNA regulatory mechanism involving miR-1205 and FoxP3/FoxP3 mRNA to regulate CD4 + T cell differentiation and SLE activity. |
| Biological pathway or process: |
ceRNA regulation (other); immune regulation (other); inflammation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Luciferase Reporter Assay; Western Blot; IF (Immunofluorescence); BrdU; Flow Cytometry（Non-apoptosis/cycle）; In Vivo Animal Model; H&E Staining; ELISA |
| Clinical significance: |
circETS1 expression was significantly down-regulated in CD4 + T cells of SLE patients and correlated with C3, ANA, and dsDNA; the circETS1/miR-1205/FoxP3 axis may be a novel target for SLE therapy. |
| Description: |
circETS1 is down-regulated in CD4 + T cells from SLE patients. The study proposes that circETS1 participates in a ceRNA regulatory axis with miR-1205 and FoxP3/FoxP3 mRNA, influencing CD4 + T cell differentiation and Th17/Treg imbalance in SLE. circETS1-related regulation may have therapeutic relevance for SLE activity. |
| Confidence score: |
0.6287 |