circRNA basic information
circBase ID: hsa_circ_0007031
Name: hsa_circ_TUBGCP3
Synonym: -
Host Gene: TUBGCP3
Genomic location(hg19): chr13:113158345-113181798:-
Genomic location(hg38): chr13:112504031-112527484:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HCT116; CRR-HCT116
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: AKT3, BCL2
Associated microRNA: miR-885-3p
Biological function: unknown
Molecular mechanism: Predicted miRNA sponge/ceRNA interactions (e.g., with miR-885-3p) and predicted regulation of cancer-related genes (AKT3, BCL2).
Biological pathway or process:

ceRNA regulation (other); PI3K/AKT (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0007031 is strongly upregulated in 5-FU-based chemoradiation-resistant CRC cells and is predicted to act through miRNA-mediated regulation (e.g., involving miR-885-3p). It is also predicted (as a top upregulated circRNA) to influence cancer-related targets such as AKT3 and BCL2, potentially contributing to chemoradiation resistance.
Confidence score:

0.2465
Other information
Title:

Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.

Journal: BioMed research international
Published: 2017
PubMed ID: 28656150
Study type:

biological research; bioinformatics study
Data availability: -
Code availability: -