| Expression pattern: |
DN |
| Associated gene: |
HHIP |
| Associated microRNA: |
miR-630, miR-223-5p |
| Biological function: |
inhibits proliferation, migration and invasion; promotes apoptosis; suppresses tumor growth in vivo |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-630 to upregulate HHIP. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Luciferase Reporter Assay; RNA Pull-Down; Bioinformatics Analysis; ROC Analysis; Clinical Sample Validation |
| Clinical significance: |
circFAM114A2 was associated with microvascular invasion and lymph node metastasis of HCC patients; plasma circFAM114A2 may serve as an effective biomarker to screen HCC patients from healthy controls (AUC=0.922). |
| Description: |
circFAM114A2 is down-regulated in HCC tissues and plasma and suppresses HCC cell proliferation, migration, and invasion while promoting apoptosis. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-630 to upregulate the tumor suppressor HHIP. Plasma circFAM114A2 shows diagnostic potential for distinguishing HCC patients from healthy controls. |
| Confidence score: |
0.8837 |