| Expression pattern: |
UP |
| Associated gene: |
Rab10 |
| Associated microRNA: |
miR-422a |
| Biological function: |
circUBAP2 acts as an oncogene in ESCC; it promotes proliferation, migration, invasion and tumour growth, while circUBAP2 knockdown inhibits proliferation, migration, invasion and xenograft tumour growth. |
| Molecular mechanism: |
circUBAP2 functions as a ceRNA by sponging miR-422a, thereby regulating the miR-422a/Rab10 axis in ESCC cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circUBAP2 might be a therapeutic target for the treatment of ESCC. |
| Description: |
This study reports that circUBAP2 is upregulated in ESCC tumour tissues and ESCC cell lines. Functional assays indicate that circUBAP2 promotes ESCC cell proliferation, migration, invasion and xenograft tumour growth. Mechanistically, circUBAP2 acts as an oncogenic ceRNA by sponging miR-422a and regulating Rab10, suggesting potential therapeutic relevance in ESCC. |
| Confidence score: |
0.6521 |