| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
circPDK1 is overexpressed in LSCC tissues, associated with fewer lymph nodes metastasis, less vascular invasion, less visceral pleural invasion, and better RFS/OS, suggesting an antitumor function and prognostic biomarker role in resected LSCC. |
| Molecular mechanism: |
The underlying molecular biological mechanism was not experimentally defined; circPDK1 was reported to be transcribed from the PDK1 gene and negatively correlated with linear PDK1 expression. |
| Biological pathway or process: |
metastasis (inhibits); invasion (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
circPDK1 was identified as a potential prognostic biomarker of resected LSCC; elevated circPDK1 indicated better RFS and OS and was included in a nomogram model predicting 5-year RFS and OS. |
| Description: |
circPDK1 is a PDK1-derived circular RNA that is up-regulated in resected LSCC tissues compared with adjacent normal lung tissues. Higher circPDK1 expression was associated with fewer metastatic/invasive clinicopathological features and better RFS/OS, and it was incorporated with T staging, lymph node status, age, and SCCAg into a prognostic nomogram for 5-year RFS and OS prediction. The study did not define a detailed molecular mechanism. |
| Confidence score: |
0.5202 |