| Expression pattern: |
DN |
| Associated gene: |
BMPR2 |
| Associated microRNA: |
miR-1206 |
| Biological function: |
Inhibits viability, proliferation, adhesion, migration and invasion, and induces apoptosis of LAC cells (tumor suppressor). |
| Molecular mechanism: |
ceRNA mechanism: circ_0129047 sponges miR-1206 to relieve repression of BMPR2, thereby inhibiting LAC progression. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; BrdU; ELISA; Transwell Assay; Wound Healing Assay; Clinical Sample Validation; Bioinformatics Analysis; Microarray |
| Clinical significance: |
- |
| Description: |
circ_0129047 is down-regulated in lung adenocarcinoma tissues/cell lines and functions as a tumor suppressor. It mainly localizes to the cytoplasm and inhibits malignant phenotypes by sponging miR-1206, thereby upregulating BMPR2. |
| Confidence score: |
0.8067 |