| Expression pattern: |
UP |
| Associated gene: |
TFCP2, YAP, SOX9, FOXM1, BIRC5, CTGF |
| Associated microRNA: |
miR-136 |
| Biological function: |
hsa_circ_0023404 exerts an oncogenic role in cervical cancer; its knockdown suppresses proliferation and colony formation, arrests cell-cycle progression, and inhibits migration and invasion. |
| Molecular mechanism: |
hsa_circ_0023404 acts as a sponge of miR-136, promotes TFCP2 expression, and activates the YAP signaling pathway in cervical cancer. |
| Biological pathway or process: |
Hippo/YAP (promotes); proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0023404 overexpression was correlated with poor prognosis and may be a prognostic biomarker or therapeutic target for cervical cancer. |
| Description: |
hsa_circ_0023404 is up-regulated in cervical cancer tissues and cell lines, and high expression predicts poor prognosis. Functionally, it promotes cervical cancer cell proliferation, cell-cycle progression, migration and invasion. Mechanistically, it acts as a miR-136 sponge to increase TFCP2 expression and activate YAP signaling. |
| Confidence score: |
0.7113 |