| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
May serve a role in the development/pathophysiology of traumatic lung injury and has potential diagnostic biomarker value. |
| Molecular mechanism: |
Bioinformatically predicted ceRNA network (circRNA-miRNA-mRNA) based on the validated circRNAs; specific miRNA/mRNA pairs for this circRNA not specified in the provided text. |
| Biological pathway or process: |
ceRNA regulation (other); PI3K/AKT/mTOR (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
ROC analysis showed hsa_circ_102927 could distinguish TLI plasma from normal controls (AUC 0.978; specificity 95.0%; sensitivity 95.0%). |
| Description: |
hsa_circRNA_102927 (host gene RHBDD1) is down-regulated in plasma from traumatic lung injury patients and shows strong diagnostic discrimination by ROC analysis. The study further places it within a predicted ceRNA (circRNA-miRNA-mRNA) network potentially relevant to TLI pathophysiology. |
| Confidence score: |
0.5963 |