circRNA basic information
circBase ID: hsa_circ_0008305
Name: hsa_circ_PTK2
Synonym: circPTK2
Host Gene: PTK2
Genomic location(hg19): chr8:141799572-141840625:-
Genomic location(hg38): chr8:140789473-140830526:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: Hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent tissues
Cell lines:

293T; Hep3B; MHCC-97L
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: E-cadherin
Associated microRNA: miR-92a, miR-92a-3p
Biological function: circPTK2 inhibits EMT, suppresses HCC cell invasion, and inhibits progression and metastasis of HCC.
Molecular mechanism: circPTK2 acts as a ceRNA and sponges miR-92a to upregulate E-cadherin expression.
Biological pathway or process:

EMT (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

Luciferase Reporter Assay; Transfection; RT-qPCR; Western Blot; Transwell Assay; Bioinformatics Analysis
Clinical significance:

The circPTK2/miR-92a/E-cadherin regulatory axis may serve as a valuable biomarker and therapeutic target for patients with HCC.
Description:

This study identifies circPTK2, also named hsa_circ_0008305, as a suppressive circRNA in HCC cell invasion, EMT, progression, and metastasis. Mechanistically, circPTK2 acts as a ceRNA that binds miR-92a and relieves miR-92a-mediated repression of E-cadherin, forming the circPTK2/miR-92a/E-cadherin axis.
Confidence score:

0.5416
Other information
Title:

The circular RNA circPTK2 inhibits EMT in hepatocellular carcinoma by acting as a ceRNA and sponging miR-92a to upregulate E-cadherin.

Journal: European review for medical and pharmacological sciences
Published: 2020
PubMed ID: 33015774
Study type:

biological research
Data availability: The Cancer Genome Atlas database (TC-GA)
Code availability: -