circRNA basic information
circBase ID: -
Name: hsa_circ_LARP4
Synonym: -
Host Gene: LARP4
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; adjacent tissue
Cell lines:

HMEC; MCF‐7; BT474; MDA‐MB‐231; MDA‐MB‐468
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: p53, p21, runt‐related transcription factor 3
Associated microRNA: miR‐424, miR‐761
Biological function: Promotes chemosensitivity to doxorubicin; associated with reduced tumor stage and better prognosis in breast cancer.
Molecular mechanism: not specified
Biological pathway or process:

drug resistance (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; CCK8
Clinical significance:

Higher tumor circ-LARP4 correlates with increased DFS and OS; potential prognostic biomarker.
Description:

circ-LARP4 is down-regulated in breast cancer tumor tissues and breast cancer cell lines compared with controls. Higher tumor circ-LARP4 levels are associated with earlier stage and better DFS/OS. Overexpression of circ-LARP4 increases doxorubicin sensitivity in MCF-7 and MDA-MB-231 cells.
Confidence score:

0.6866
Other information
Title:

Circular RNA La-related RNA-binding protein 4 correlates with reduced tumor stage, as well as better prognosis, and promotes chemosensitivity to doxorubicin in breast cancer.

Journal: Journal of clinical laboratory analysis
Published: 2020
PubMed ID: 32187743
Study type:

combined biological and clinical study
Data availability: Tissue‐Specific CircRNA Database (http://gb.whu.edu.cn/TSCD/)
Code availability: -