circRNA basic information
circBase ID: hsa_circ_0001821
Name: hsa_circ_PVT1
Synonym: hsa_Circ_0001821 / circ-PVT1
Host Gene: PVT1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HCT116
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: FGF-2, BAX, BCL-2
Associated microRNA: hsa-miR-203a-3p
Biological function: Promotes CRC cell viability and migration, inhibits apoptosis, and increases cellular resistance to 5-FU.
Molecular mechanism: Acts as a molecular sponge for hsa-miR-203a-3p, thereby increasing FGF-2 expression and influencing 5-FU response.
Biological pathway or process:

proliferation (promotes); migration (promotes); apoptosis (inhibits); chemoresistance (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; MTT; Wound Healing Assay; Annexin V/PI Flow Cytometry; Bioinformatics Analysis
Clinical significance:

-
Description:

In HCT116 colorectal cancer cells, hsa_Circ_0001821 (circ-PVT1) promotes malignant phenotypes and 5-FU chemoresistance by sponging hsa-miR-203a-3p to maintain higher FGF-2 expression. Silencing hsa_Circ_0001821 decreases viability and migration and increases apoptosis, enhancing sensitivity to 5-FU.
Confidence score:

0.4546
Other information
Title:

Role of hsa_Circ_0001821 in Colorectal Cancer Pathogenesis and Response to 5-Fluorouracil through miR-203a-3p/FGF-2 Axis.

Journal: Iranian biomedical journal
Published: 2025
PubMed ID: 40231340
Study type:

biological research
Data availability: The data generated and analyzed during the current study are not publicly available but are available from the corresponding author on reasonable request.
Code availability: -