circRNA basic information
circBase ID: hsa_circ_0049271
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr19:10610070-10610756:-
Genomic location(hg38): chr19:10499394-10500080:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissue; adjacent healthy tissue; tumor-adjacent tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: 62 miRNAs
Biological function: Predicted differentially expressed tumor suppressor circRNA in NSCLC, serving as a potential miRNA sponge and associated with regulation of cell cycle, inflammatory response, and proliferation.
Molecular mechanism: Predicted miRNA sponge mechanism based on CSCD database functional analysis.
Biological pathway or process:

ceRNA regulation (other); proliferation (inhibits); cell cycle (other); inflammation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

Potential molecular marker for NSCLC based on bioinformatics prediction.
Description:

hsa_circ_0049271 was identified as a downregulated circRNA in NSCLC tissues using three GEO microarray datasets. Its functional role was predicted bioinformatically, mainly as a miRNA sponge with possible tumor suppressor relevance.
Confidence score:

0.1768
Other information
Title:

Bioinformatics Analysis Predicts hsa_circ_0026337/miR-197-3p as a Potential Oncogenic ceRNA Network for Non-Small Cell Lung Cancers.

Journal: Anti-cancer agents in medicinal chemistry
Published: 2022
PubMed ID: 34254931
Study type:

bioinformatics study
Data availability: GSE158695; GSE112214; GSE101684; CSCD
Code availability: -