| Expression pattern: |
UN |
| Associated gene: |
MYC protein |
| Associated microRNA: |
- |
| Biological function: |
CircPVT1 contributes to stabilization of MYC protein in prostate cancer, especially in pure Gleason pattern 4; silencing circPVT1 decreases MYC protein expression in prostate cancer cells. |
| Molecular mechanism: |
CircPVT1 acts as a circular RNA splicing variant derived from PVT1 and appears to preferentially support MYC protein expression/stability; siRNA-mediated suppression of circPVT1 reduces MYC protein. |
| Biological pathway or process: |
other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Western Blot; IHC (Immunohistochemistry) |
| Clinical significance: |
Detection of circPVT1 by in situ hybridization is proposed as potentially helpful for differential diagnosis between Gleason score 3 + 4 and 4 + 3, but this was described as a next step rather than performed in the study. |
| Description: |
This study investigated circPVT1 in prostate cancer, especially pure Gleason pattern 4, and found that circPVT1 suppression in DU145 prostate cancer cells reduced MYC protein expression. The authors conclude that circular PVT1 may preferentially contribute to MYC protein stabilization in GP4 prostate cancer, suggesting a distinct biological feature of this Gleason pattern. |
| Confidence score: |
0.5736 |