circRNA basic information
circBase ID: -
Name: hsa_circ_FBXW7
Synonym: hsa_circ_001988
Host Gene: FBXW7
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

colorectal cancer tissue; normal colon mucosa; tumor tissues; adjacent normal mucosa
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: hsa_circ_001988 may serve as a potential biomarker for colorectal cancer diagnosis and may be associated with differentiation and perineural invasion; functional mechanisms were not experimentally explored.
Molecular mechanism: -
Biological pathway or process:

invasion (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

hsa_circ_001988 expression was significantly correlated with differentiation and perineural invasion; ROC AUC was 0.788, suggesting potential diagnostic biomarker value in colorectal cancer.
Description:

This study validated the existence of hsa_circ_001988 in human colorectal cancer tissues and normal mucosa, and showed that it is significantly down-regulated in colorectal cancer. Its expression was associated with tumor differentiation and perineural invasion, and ROC analysis suggested potential diagnostic biomarker value. No specific molecular mechanism or interacting miRNA/protein axis was experimentally defined.
Confidence score:

0.5958
Other information
Title:

Decreased expression of hsa_circ_001988 in colorectal cancer and its clinical significances.

Journal: International journal of clinical and experimental pathology
Published: 2015
PubMed ID: 26884878
Study type:

combined biological and clinical study
Data availability: next generation sequence data base generated in house
Code availability: -