| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-7978, hsa-miR-6727-3p, let-7a-2-3p, hsa-miR-1202, let-7c-3p, hsa-miR-4793-5p, hsa-miR-4722-3p, hsa-miR-3194-5p, hsa-miR-3972, hsa-miR-4327, hsa-miR-4679 |
| Biological function: |
May function as a competing endogenous RNA and play vital roles in BCa development; its expression in serum exosomes may have value for BCa prediction. |
| Molecular mechanism: |
Predicted ceRNA/miRNA sponge mechanism; overexpression of hsa-circRNA-0088088 reduced let-7a-2-3p levels, supporting the hsa-circRNA-0088088/let-7a-2-3p interaction. |
| Biological pathway or process: |
ceRNA regulation (other); Wnt/beta-catenin (other); TGF-beta/SMAD (other); Hippo/YAP (other); other pathway/process (other) |
| Detected method: |
Q
S
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; RNA-seq; Microarray; Clinical Sample Validation; Bioinformatics Analysis; Transfection |
| Clinical significance: |
May serve as a stable exosomal biomarker for predicting BCa tumorigenesis, development and metastasis. |
| Description: |
hsa-circRNA-0088088 is up-regulated in breast cancer serum exosomes and tissues. The study proposes that it may act as an exosomal ceRNA/miRNA sponge, especially through the hsa-circRNA-0088088/let-7a-2-3p interaction, and may have biomarker value for BCa prediction. |
| Confidence score: |
0.695 |