| Expression pattern: |
UP |
| Associated gene: |
SOX12 |
| Associated microRNA: |
miR-625-5p |
| Biological function: |
circ_0012152 acts as an oncogene in AML; it promotes AML cell proliferation and cell-cycle progression and inhibits cell death/apoptosis. |
| Molecular mechanism: |
circ_0012152 sponges/targets miR-625-5p and relieves miR-625-5p-mediated inhibition of SOX12, thereby upregulating SOX12 in AML cells. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; Transfection; MTT; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation) |
| Clinical significance: |
High circ_0012152 expression was associated with significantly lower overall survival in AML patients and may provide diagnostic markers or potential therapeutic targets for AML. |
| Description: |
circ_0012152 is upregulated in AML tissues and cell lines and high expression is associated with poorer overall survival. Functionally, circ_0012152 promotes AML cell proliferation and cell-cycle progression while inhibiting cell death/apoptosis. Mechanistically, it acts through the miR-625-5p/SOX12 axis by suppressing miR-625-5p activity and increasing SOX12 expression. |
| Confidence score: |
0.7789 |