| Expression pattern: |
UP |
| Associated gene: |
CYR61 |
| Associated microRNA: |
miR-515-5p |
| Biological function: |
promotes breast cancer cell multiplication, migration, and invasion |
| Molecular mechanism: |
circ_0103552 acts as a ceRNA by sponging miR-515-5p, thereby up-modulating CYR61 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; Survival Analysis |
| Clinical significance: |
high expression of circ_0103552 was associated with larger tumor size, positive lymphatic metastasis, and shorter overall survival in breast cancer patients |
| Description: |
hsa_circ_0103552/circ_0103552 is up-regulated in breast cancer tissues and cell lines and is associated with adverse clinicopathological features and poor overall survival. Functionally, it promotes breast cancer cell proliferation, migration, and invasion. Mechanistically, circ_0103552 acts as a ceRNA for miR-515-5p to increase CYR61 expression. |
| Confidence score: |
0.7325 |