circRNA basic information
circBase ID: -
Name: hsa_circ_PLK1
Synonym: circPLK1 / hsa_circ_038632
Host Gene: PLK1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005494
MONDO name: triple-negative breast carcinoma
Disease details: triple-negative breast cancer / TNBC
Disease DO ID:
 0060081
Disease MeSH ID:
 D064726
Disease NCIt ID:
 C71732
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

TNBC tumor tissue; normal breast tissue; non-cancerous matched breast tissue (NCMT)
Cell lines:

MCF-10A; 184A1; MDA-MB-231; BT549; MDA-MB-468; MDA-MB-231/ADR; HEK 293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: ETS1, AGO2
Associated microRNA: miR-940
Biological function: promotes anthracycline (doxorubicin) resistance; promotes colony formation and cell viability; suppresses doxorubicin-induced apoptosis
Molecular mechanism: circPLK1 acts as a miRNA sponge for miR-940, thereby upregulating ETS1
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); chemoresistance (promotes)
Detected method:
Q
H
M
Validation methods:

Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; ISH (In Situ Hybridization); Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; EdU Staining; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis
Clinical significance:

High circPLK1 expression is associated with non-pCR to anthracyclines-based neoadjuvant chemotherapy and reduced DFS/OS in TNBC.
Description:

circPLK1 is upregulated in TNBC, especially in non-pCR patients after anthracyclines-based neoadjuvant chemotherapy. It promotes doxorubicin/anthracycline resistance by sponging miR-940 and thereby increasing ETS1 expression, leading to enhanced survival/colony formation and reduced apoptosis. High circPLK1 is associated with poorer DFS/OS and may serve as a prognostic/pharmacodynamic biomarker.
Confidence score:

0.8711
Other information
Title:

CircPLK1 upregulates ETS1 to confer anthracycline resistance in triple-negative breast cancer.

Journal: Journal of translational internal medicine
Published: 2025
PubMed ID: 40896288
Study type:

combined biological and clinical study
Data availability: The datasets used in the study are available from the corresponding author on reasonable request.
Code availability: -