| Expression pattern: |
DN |
| Associated gene: |
YAP1, beta-catenin |
| Associated microRNA: |
miR-31-5p |
| Biological function: |
Suppresses CRC cell proliferation, invasion and migration; inhibits CRC cell growth and migration. |
| Molecular mechanism: |
CircPSMC3 functions through a ceRNA/sponging mechanism by binding miR-31-5p and modulating the YAP/beta-catenin axis. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other); Hippo/YAP (inhibits); Wnt/beta-catenin (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
CircPSMC3 may serve as a useful therapeutic candidate for CRC. |
| Description: |
CircPSMC3 is down-regulated in colorectal cancer tissues and cell lines. Its overexpression suppresses CRC cell proliferation, invasion and migration by sponging miR-31-5p and modulating the YAP/beta-catenin axis, suggesting potential therapeutic relevance. |
| Confidence score: |
0.6536 |