| Expression pattern: |
DN |
| Associated gene: |
SOCS2 |
| Associated microRNA: |
miR-1204 |
| Biological function: |
CircITFG2 overexpression restrained CRC cell viability, clonality, migration and invasion, promoted apoptosis, and mediated lidocaine-induced inhibition of proliferation and metastasis and promotion of apoptosis. |
| Molecular mechanism: |
CircITFG2 functions as a molecular sponge for miR-1204 and negatively regulates miR-1204, thereby modulating SOCS2 expression in lidocaine-treated CRC cells. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot |
| Clinical significance: |
- |
| Description: |
circITFG2 is down-regulated in colorectal cancer cells and tissues and acts as a tumor suppressive circRNA. It inhibits proliferation, colony formation, migration and invasion while promoting apoptosis, and it mediates lidocaine-induced anti-CRC effects through the circITFG2/miR-1204/SOCS2 axis. |
| Confidence score: |
0.7294 |