circRNA basic information
circBase ID: hsa_circ_0070467
Name: hsa_circ_PDLIM5
Synonym: circP-DLIM5 / circPDLIM5
Host Gene: PDLIM5
Genomic location(hg19): chr4:95494501-95507595:+
Genomic location(hg38): chr4:94573350-94586444:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HCC827; HCC827-OR
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Inhibits proliferation, migration and angiogenesis; promotes apoptosis in osimertinib-resistant NSCLC cells (HCC827-OR).
Molecular mechanism: Not specified (functional effects shown by knockdown/overexpression; no miRNA/protein axis reported).
Biological pathway or process:

proliferation (inhibits); migration (inhibits); angiogenesis (inhibits); apoptosis (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Tube Formation Assay; Bioinformatics Analysis
Clinical significance:

-
Description:

circPDLIM5 (hsa_circ_0070467) is down-regulated in osimertinib-resistant HCC827-OR cells. Functionally, circPDLIM5 acts as a suppressive circRNA in the resistant context: its knockdown enhances proliferation, migration and angiogenesis and reduces apoptosis, while overexpression shows opposite effects.
Confidence score:

0.6874
Other information
Title:

Characterization of circRNAs in established osimertinib‑resistant non‑small cell lung cancer cell lines.

Journal: International journal of molecular medicine
Published: 2023
PubMed ID: 37681495
Study type:

biological research
Data availability: PRJNA1000087; PRJNA1000497
Code availability: -