| Expression pattern: |
UP |
| Associated gene: |
CXCL8 |
| Associated microRNA: |
hsa-miR-4428, hsa-miR-4433a-3p, hsa-miR-4667-5p, hsa-miR-4780, hsa-miR-5006-5p, hsa-miR-5588-5p, hsa-miR-6875-3p, hsa-miR-6891-5p, hsa-miR-885-3p |
| Biological function: |
Might upregulate CXCL8 by adsorbing miRNAs and was associated with immune cell infiltration in cervical cancer. |
| Molecular mechanism: |
Predicted ceRNA mechanism in which hsa circ 0001307 may sponge miRNAs to upregulate CXCL8. |
| Biological pathway or process: |
ceRNA regulation (promotes); immune regulation (other); inflammation (promotes) |
| Detected method: |
S
|
| Validation methods: |
circRNA-seq; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
hsa circ 0001307 was identified as an up-regulated cervical cancer circRNA in the predicted circRNA-miRNA-CXCL8 network. The study suggests that it may regulate CXCL8 through miRNA sponging and that it is associated with monocytes, activated mast cells and activated memory CD4 T cells. |
| Confidence score: |
0.3991 |