| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-101-3p (miR-101), miR-101 |
| Biological function: |
circVAPA promotes CRC cell proliferation, colony formation, migration and invasion, inhibits apoptosis, and promotes CRC progression. |
| Molecular mechanism: |
circVAPA acts as a ceRNA by sponging miR-101; the tumor-promoting effect of circVAPA over-expression is reversed by miR-101 up-regulation. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circVAPA level was associated with unfavorable clinicopathologic features in CRC, and plasma circVAPA could serve as a promising non-invasive biomarker for CRC detection. |
| Description: |
circVAPA (hsa_circ_0006990), derived from VAPA, is up-regulated in CRC tissues and plasma. It promotes malignant phenotypes of CRC cells by enhancing proliferation, migration and invasion while inhibiting apoptosis, at least partly through sponging miR-101. Plasma circVAPA shows diagnostic potential for CRC and its high level is associated with unfavorable clinicopathologic features. |
| Confidence score: |
0.8448 |