| Expression pattern: |
UP |
| Associated gene: |
LMO4 |
| Associated microRNA: |
miR-370-3p |
| Biological function: |
promotes proliferation and colony formation, promotes migration and invasion, inhibits apoptosis, and promotes tumor growth in papillary thyroid carcinoma |
| Molecular mechanism: |
ceRNA mechanism: circ_0058124 acts as a sponge for miR-370-3p, thereby upregulating LMO4 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
might be used as a promising biomarker for PTC diagnosis and treatment |
| Description: |
circ_0058124 is up-regulated in papillary thyroid carcinoma tissues and cell lines and acts as an oncogenic circRNA. It promotes PTC cell proliferation, migration and invasion and suppresses apoptosis by sponging miR-370-3p to increase LMO4 expression (circ_0058124/miR-370-3p/LMO4 axis), and its knockdown inhibits xenograft tumor growth. |
| Confidence score: |
0.795 |