circRNA basic information
circBase ID: hsa_circ_0058124
Name: hsa_circ_FN1
Synonym: circ_0058124
Host Gene: FN1
Genomic location(hg19): chr2:216270960-216274462:-
Genomic location(hg38): chr2:215406237-215409739:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid carcinoma
Disease DO ID:
3969
Disease MeSH ID:
-
Disease NCIt ID:
C4035
Disease ICD11 ID:
-
Disease OMIM ID:
-
Species: Human
Species details: Homo sapiens
Tissue specimen:

PTC tissues; normal tissues; tumor tissues; non-tumor tissues

Cell lines:

Nthy-ori 3-1; IHH-4; TPC-1

In vivo animal model:

cell line-derived xenograft

circRNA-disease information
Expression pattern:
UP
Associated gene: LMO4
Associated microRNA: miR-370-3p
Biological function: promotes proliferation and colony formation, promotes migration and invasion, inhibits apoptosis, and promotes tumor growth in papillary thyroid carcinoma
Molecular mechanism: ceRNA mechanism: circ_0058124 acts as a sponge for miR-370-3p, thereby upregulating LMO4
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)

Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model

Clinical significance:

might be used as a promising biomarker for PTC diagnosis and treatment

Description:

circ_0058124 is up-regulated in papillary thyroid carcinoma tissues and cell lines and acts as an oncogenic circRNA. It promotes PTC cell proliferation, migration and invasion and suppresses apoptosis by sponging miR-370-3p to increase LMO4 expression (circ_0058124/miR-370-3p/LMO4 axis), and its knockdown inhibits xenograft tumor growth.

Confidence score:

0.795

Other information
Title:

Circ_0058124 Aggravates the Progression of Papillary Thyroid Carcinoma by Activating LMO4 Expression via Targeting miR-370-3p.

Journal: Cancer management and research
Published: 2020
PubMed ID: 33061633
Study type:

combined biological and clinical study

Data availability: -
Code availability: -