circRNA basic information
circBase ID: hsa_circ_0003028
Name: hsa_circ_FUT8
Synonym: circ_0003028
Host Gene: FUT8
Genomic location(hg19): chr14:66028054-66028484:+
Genomic location(hg38): chr14:65561336-65561766:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
3908
Disease MeSH ID:
D002289
Disease NCIt ID:
C2926
Disease ICD11 ID:
-
Disease OMIM ID:
-
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tumor tissue; adjacent normal tissues

Cell lines:

A-549; NCI-H1299; NCI-H460; BEAS-2B; HUVEC

In vivo animal model:

cell line-derived xenograft

circRNA-disease information
Expression pattern:
UP
Associated gene: GOT2, Ago2
Associated microRNA: miR-1298-5p
Biological function: promotes proliferation, cell cycle progression, migration, invasion, angiogenesis and tumor growth; inhibits apoptosis and autophagy in NSCLC cells
Molecular mechanism: ceRNA mechanism: circ_0003028 sponges miR-1298-5p to regulate GOT2 expression
Biological pathway or process:

proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); angiogenesis (promotes); autophagy (inhibits); ceRNA regulation (promotes)

Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation

Clinical significance:

-

Description:

circ_0003028 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, angiogenesis) and tumor growth by sponging miR-1298-5p to increase GOT2 expression, while its knockdown increases apoptosis and autophagy.

Confidence score:

0.8201

Other information
Title:

Circular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer.

Journal: Bioengineered
Published: 2021
PubMed ID: 34077306
Study type:

combined biological and clinical study

Data availability: All data generated or analysed during this study are included in this published article (and its supplementary information files).
Code availability: -