| Expression pattern: |
UP |
| Associated gene: |
GREM1, SFMBT2 |
| Associated microRNA: |
miR-1236-3p |
| Biological function: |
Promotes cervical cancer cell proliferation, EMT, migration, invasion, HUVEC tube formation and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0000212 acts as a competing endogenous RNA for miR-1236-3p to regulate GREM1 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); angiogenesis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; EdU Staining; Western Blot; Annexin V/PI Flow Cytometry; Tube Formation Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0000212 is up-regulated in human cervical cancer tissues and cell lines and is mainly localized in the cytoplasm. It promotes cervical cancer progression by acting as a ceRNA for miR-1236-3p to increase GREM1 expression, thereby enhancing proliferation, EMT, migration, invasion, angiogenic tube formation and xenograft tumor growth while suppressing apoptosis. |
| Confidence score: |
0.7859 |