| Expression pattern: |
UP |
| Associated gene: |
dihydrofolate reductase, myosin-1E, fidgetin-like 2 |
| Associated microRNA: |
hsa-miR-23b-5p, hsa-miR-93-3p, hsa-miR-581, hsa-miR-23a-5p |
| Biological function: |
May promote tumor growth and contribute to HCC development; predicted to participate in cell adhesion. |
| Molecular mechanism: |
Predicted ceRNA/miRNA sponge mechanism involving hsa-miR-23b-5p, hsa-miR-93-3p, hsa-miR-581 and hsa-miR-23a-5p, with downstream mRNAs predicted by TargetScan and miRanda. |
| Biological pathway or process: |
cell adhesion (other); ceRNA regulation (other); proliferation (promotes); invasion (other); metastasis (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; divergent primers PCR; Bioinformatics Analysis; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
hsa_circ_0005075 expression correlated with HCC tumor size and showed good diagnostic potential (AUROC=0.94; sensitivity 83.3%, specificity 90.0%). |
| Description: |
hsa_circ_0005075 is significantly up-regulated in HCC tissues and is associated with larger tumor size, suggesting a tumor-promoting role. Mechanistically, it is predicted to act as a miRNA sponge (e.g., hsa-miR-23b-5p, hsa-miR-93-3p, hsa-miR-581, hsa-miR-23a-5p) and to be involved in a miRNA-mRNA network enriched for cell-adhesion-related processes. It shows strong diagnostic potential for distinguishing HCC from adjacent nontumorous tissues (AUROC 0.94). |
| Confidence score: |
0.6556 |