circRNA basic information
circBase ID: hsa_circ_0043949
Name: -
Synonym: circ_0043949
Host Gene: -
Genomic location(hg19): chr17:41201137-41209152:-
Genomic location(hg38): chr17:43049120-43057135:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018177
MONDO name: glioblastoma
Disease details: glioblastoma / GBM
Disease DO ID:
 3068
Disease MeSH ID:
 D005909
Disease NCIt ID:
 C3058
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

secondary temozolomide-resistant glioblastoma tissues; matched primary glioblastoma tissues; GBM tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-7161-3p, hsa-miR-6783-3p, hsa-miR-1257, hsa-miR-140-3p, hsa-miR-5195-3p
Biological function: High expression is closely related to chemoresistance of secondary temozolomide-resistant glioblastoma; it might serve as a potential therapeutic target and prognostic biomarker for glioblastoma.
Molecular mechanism: Predicted circRNA-miRNA interaction/ceRNA mechanism involving hsa-miR-7161-3p, hsa-miR-6783-3p, hsa-miR-1257, hsa-miR-140-3p and hsa-miR-5195-3p.
Biological pathway or process:

ceRNA regulation (other); chemoresistance (promotes)
Detected method:
Q
M
Validation methods:

RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Might be a potential therapeutic target and prognostic biomarker for the treatment of glioblastoma.
Description:

hsa_circ_0043949 was up-regulated in secondary temozolomide-resistant glioblastoma and validated by qRT-PCR. The study links its high expression to TMZ chemoresistance and predicts that it may act through circRNA-miRNA interactions involving several candidate miRNAs, including hsa-miR-140-3p.
Confidence score:

0.4032
Other information
Title:

Microarray expression profiles and bioinformatics analysis of mRNAs, lncRNAs, and circRNAs in the secondary temozolomide-resistant glioblastoma.

Journal: Investigational new drugs
Published: 2020
PubMed ID: 31823158
Study type:

combined clinical and bioinformatics study
Data availability: GSE139826
Code availability: -