circRNA basic information
circBase ID: -
Name: hsa_circ_ADAM9
Synonym: circ-ADAM9
Host Gene: ADAM9
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009831
MONDO name: malignant pancreatic neoplasm
Disease details: pancreatic cancer / PC
Disease DO ID:
 1793
Disease MeSH ID:
 -
Disease NCIt ID:
 C9005
Disease ICD11 ID:
 542147910
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PC tissues; matched normal tissues; tumour tissues
Cell lines:

PANC1; MiaPaca2; SW1990; Capan1; BxPC3; HPDE
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: PRSS3, pERK, ERK, VEGF
Associated microRNA: miR-217
Biological function: circ-ADAM9 promotes pancreatic cancer cell proliferation, migration, invasion and tumour growth, and its silencing retards tumour growth in vivo.
Molecular mechanism: circ-ADAM9 acts as a ceRNA that sponges and inhibits miR-217, relieving miR-217-mediated repression of PRSS3 and activating ERK/VEGF signalling.
Biological pathway or process:

ceRNA regulation (promotes); ERK (promotes); VEGF/VEGFR (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High circ-ADAM9 expression is closely associated with advanced clinical stage, lymph node metastasis, and shorter survival time in pancreatic cancer patients.
Description:

circ-ADAM9 is up-regulated in pancreatic cancer tissues and cell lines and is associated with advanced TNM stage, lymph node metastasis, and poor survival. Functionally, it promotes proliferation, migration, invasion, and xenograft tumour growth by sponging miR-217, increasing PRSS3 expression, and activating ERK/VEGF signalling.
Confidence score:

0.7537
Other information
Title:

Circular RNA ADAM9 facilitates the malignant behaviours of pancreatic cancer by sponging miR-217 and upregulating PRSS3 expression.

Journal: Artificial cells, nanomedicine, and biotechnology
Published: 2019
PubMed ID: 31810373
Study type:

combined biological and clinical study
Data availability: TCGA database; starBase V2.0 online database
Code availability: -