circRNA basic information
circBase ID: hsa_circ_0003546
Name: hsa_circ_DENND5A
Synonym: -
Host Gene: DENN-D5A
Genomic location(hg19): chr11:9215040-9229179:-
Genomic location(hg38): chr11:9193493-9207632:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005311
MONDO name: atherosclerosis
Disease details: atherosclerosis
Disease DO ID:
 1936
Disease MeSH ID:
 D050197
Disease NCIt ID:
 C35768
Disease ICD11 ID:
 109367356
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

THP-1 macrophages; THP-1 macrophage-derived foam cells
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PDE3B
Associated microRNA: miR-326
Biological function: May be involved in atherosclerosis through a predicted hsa_circ_0003546-miR-326-PDE3B ceRNA relationship and may represent a novel target.
Molecular mechanism: Predicted ceRNA mechanism: hsa_circ_0003546 may interact with miR-326 to regulate PDE3B expression.
Biological pathway or process:

ceRNA regulation (other); apoptosis (promotes); angiogenesis (inhibits)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

May provide a target for development of novel drugs for atherosclerosis.
Description:

hsa_circ_0003546 was identified as an upregulated circRNA in ox-LDL-induced foam cells. The study predicts that it may interact with miR-326 in a ceRNA axis regulating PDE3B, potentially linking it to atherosclerosis-associated apoptosis and angiogenesis regulation.
Confidence score:

0.1768
Other information
Title:

circRNA/lncRNA-miRNA-mRNA Network in Oxidized, Low-Density, Lipoprotein-Induced Foam Cells.

Journal: DNA and cell biology
Published: 2019
PubMed ID: 31804889
Study type:

bioinformatics study
Data availability: GSE107522; GSE54666; GSE54039
Code availability: -