circRNA basic information
circBase ID: hsa_circ_0005571
Name: hsa_circ_IFI30
Synonym: hsa_circRNA_0005571 / circ-0005571
Host Gene: IFI30
Genomic location(hg19): chr19:18285849-18286507:+
Genomic location(hg38): chr19:18175039-18175697:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; adjacent normal tissues
Cell lines:

NCM460; SW480; HCT116; LoVo; HT29
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: LRP8
Associated microRNA: miR-520f-3p
Biological function: promotes proliferation; promotes invasion; promotes migration; promotes in vivo tumor growth
Molecular mechanism: ceRNA mechanism: hsa_circ_0005571 sponges miR-520f-3p to derepress LRP8 expression
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Bioinformatics Analysis; Microarray; RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Colony Formation Assay; EdU Staining; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; Western Blot; Luciferase Reporter Assay
Clinical significance:

Elevated hsa_circ_0005571 expression was positively correlated with metastasis and advanced clinical stage, and high expression was associated with lower overall survival.
Description:

hsa_circ_0005571 is up-regulated in colorectal cancer tissues and cell lines and promotes CRC proliferation, migration/invasion, and xenograft tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-520f-3p to increase LRP8 expression, and high hsa_circ_0005571 levels are associated with advanced stage/metastasis and worse overall survival.
Confidence score:

0.7375
Other information
Title:

Hsa_circ_0005571 promotes the proliferation and invasion of colorectal cancer cells.

Journal: Scientific reports
Published: 2025
PubMed ID: 40846892
Study type:

combined biological and clinical study
Data availability: The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
Code availability: -