circRNA basic information
circBase ID: hsa_circ_0032883
Name: hsa_circ_EML5
Synonym: -
Host Gene: EML5
Genomic location(hg19): chr14:89220855-89221015:-
Genomic location(hg38): chr14:88754511-88754671:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum exosomes
Cell lines:

HCT116
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: May be selectively transferred via exosomes to recipient cells and associated with chemoresistance transfer.
Molecular mechanism: Bioinformatics-predicted circRNA-miRNA-mRNA associations (MRE-based).
Biological pathway or process:

ceRNA regulation (other); Wnt/beta-catenin (other); drug resistance (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Bioinformatics Analysis; Transwell Assay
Clinical significance:

hsa_circ_0032883 was significantly downregulated in serum exosomes of non-responder patients as compared to responder patients.
Description:

hsa_circ_0032883 is an exosomal circRNA associated with FOLFOX response in CRC. It was upregulated in exosomes from FOLFOX-resistant HCT116-R cells versus parental cells, but downregulated in serum exosomes of non-responder patients versus responders, suggesting context-dependent dysregulation.
Confidence score:

0.6809
Other information
Title:

Extracellular Vesicle-derived circular RNAs confers chemoresistance in Colorectal cancer.

Journal: Scientific reports
Published: 2019
PubMed ID: 31712601
Study type:

combined biological and clinical study
Data availability: Supplementary information is available for this paper at 10.1038/s41598-019-53063-y.
Code availability: -