| Expression pattern: |
UP |
| Associated gene: |
E2F6 |
| Associated microRNA: |
miR-432-5p |
| Biological function: |
Oncogenic circRNA in CRC that promotes proliferation, migration and invasion and inhibits apoptosis; circDUSP16 knockdown suppresses tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge/ceRNA: circDUSP16 binds miR-432-5p and relieves miR-432-5p-mediated repression of E2F6. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis; In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
High circDUSP16 expression was correlated with low survival rate; associated with tumor size and TNM stage. |
| Description: |
circDUSP16 is upregulated in colorectal cancer and high expression is associated with poorer overall survival. Functionally, circDUSP16 promotes CRC cell proliferation, migration and invasion and suppresses apoptosis, at least partly by sponging miR-432-5p to increase E2F6 expression; circDUSP16 knockdown inhibits xenograft tumor growth. |
| Confidence score: |
0.7548 |