circRNA basic information
circBase ID: hsa_circ_0001326
Name: hsa_circ_PHLDB2
Synonym: -
Host Gene: PHLDB2
Genomic location(hg19): chr3:111632165-111639266:+
Genomic location(hg38): chr3:111913318-111920419:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001641
MONDO name: severe pre-eclampsia
Disease details: severe preeclampsia / SPE
Disease DO ID:
 13129
Disease MeSH ID:
 -
Disease NCIt ID:
 C112843
Disease ICD11 ID:
 479404771
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

placental tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Upregulated in placental tissues of sPE patients; predicted to participate in a circRNA-miRNA-mRNA regulatory network involved in sPE pathogenesis and may function as a biomarker for diagnosis.
Molecular mechanism: Predicted ceRNA mechanism through a circRNA-miRNA-mRNA interaction network; enriched pathways included MAPK signaling pathway and other PE-related pathways.
Biological pathway or process:

MAPK (other); apoptosis (other); NF-kappaB (other); ceRNA regulation (other); invasion (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

May function as a biomarker for the diagnosis of sPE.
Description:

hsa_circ_0001326 is upregulated in placental tissues from sPE patients and was validated by RT-qPCR after RNA-seq screening. The study predicts that it may participate in sPE pathogenesis through a circRNA-miRNA-mRNA ceRNA network and may serve as a diagnostic biomarker.
Confidence score:

0.585
Other information
Title:

The expression profile of circRNA and its potential regulatory targets in the placentas of severe pre-eclampsia.

Journal: Taiwanese journal of obstetrics & gynecology
Published: 2019
PubMed ID: 31759525
Study type:

combined clinical and bioinformatics study
Data availability: -
Code availability: -