| Expression pattern: |
UP |
| Associated gene: |
AEG-1 |
| Associated microRNA: |
miR-630 |
| Biological function: |
circMTDH.4 promotes AEG-1 expression by sponging miR-630 and contributes to NSCLC cell chemoresistance and radioresistance; knockdown of circMTDH.4 increases sensitivity to chemotherapy and radiotherapy and reduces colony formation. |
| Molecular mechanism: |
ceRNA mechanism: circMTDH.4 sponges miR-630 to regulate AEG-1 expression, forming the circMTDH.4/miR-630/AEG-1 axis. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); drug resistance (promotes); chemoresistance (promotes); radioresistance (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; Colony Formation Assay |
| Clinical significance: |
circMTDH.4 is highly expressed in NSCLC tumor tissues compared with normal tissues, suggesting potential involvement in NSCLC; no circMTDH.4-specific diagnostic or prognostic performance was reported. |
| Description: |
circMTDH.4 is up-regulated in NSCLC tissues and cells. The study identifies a circMTDH.4/miR-630/AEG-1 ceRNA axis in which circMTDH.4 sponges miR-630 to increase AEG-1 expression, thereby contributing to proliferation-related effects and resistance to chemotherapy and radiotherapy in NSCLC cells. |
| Confidence score: |
0.7165 |