circRNA basic information
circBase ID: hsa_circ_0004771
Name: -
Synonym: circ_0004771
Host Gene: -
Genomic location(hg19): chr21:16386664-16415895:-
Genomic location(hg38): chr21:15014343-15043574:-
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker associated with advanced tumor stage and lymph node metastasis in CRC.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Up-regulated in CRC sera; associated with advanced TNM stage and lymph node metastasis; ROC AUC = 0.84 for discriminating CRC patients from healthy individuals.
Description:

circ_0004771 was significantly up-regulated in serum from CRC patients. Its higher expression was associated with advanced stage and lymph node metastasis, and ROC analysis suggested diagnostic potential.
Confidence score:

0.4187
Other information
Title:

Colorectal cancer-secreted exosomal circ_001422 plays a role in regulating KDR expression and activating mTOR signaling in endothelial cells by targeting miR-195-5p.

Journal: Journal of cancer research and clinical oncology
Published: 2023
PubMed ID: 37432457
Study type:

clinical study
Data availability: The data supporting the findings of this study are available from the corresponding author upon reasonable request; Supplementary material available at https:// doi. org/ 10. 1007/ s00432-023-05095-1
Code availability: -