| Expression pattern: |
UP |
| Associated gene: |
ONECUT2, EIF4A3 |
| Associated microRNA: |
miR-599 |
| Biological function: |
promotes CRC cell proliferation, migration, invasion and angiogenesis; promotes tumorigenesis in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0084615 sponges miR-599 to upregulate ONECUT2; EIF4A3 induces circ_0084615 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Tube Formation Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
Elevated circ_0084615 in CRC tissues is linked to TNM stages, lymph node metastasis, differentiation and overall survival; high circ_0084615 correlates with poor overall survival. |
| Description: |
circ_0084615 (ASPH-derived) is up-regulated in colorectal cancer and functions as an oncogenic circRNA. It promotes proliferation, migration/invasion, EMT-related changes and angiogenesis, at least partly by sponging miR-599 to increase ONECUT2, and its biogenesis is positively regulated by the RBP EIF4A3. |
| Confidence score: |
0.873 |