| Expression pattern: |
UP |
| Associated gene: |
Wnt/beta-catenin pathway, beta-catenin, c-Myc |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation, stemness, EMT and migration of surrounding normal gastric epithelial cells (GES-1) and promotes gastric cancer development |
| Molecular mechanism: |
exosomal circ0000670 promotes gastric cancer development by regulating the Wnt/beta-catenin pathway and increasing beta-catenin and c-Myc expression |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); EMT (promotes); stemness (promotes); proliferation (promotes); migration (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Agarose Gel Electrophoresis; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Western Blot; Transwell Assay; IF (Immunofluorescence) |
| Clinical significance: |
circ0000670 was up-regulated in tissues of gastric cancer patients with smoking history |
| Description: |
Exosomal circ0000670 is up-regulated in gastric cancer patients with smoking history and in cigarette smoke-exposed gastric cancer cells/exosomes. It promotes proliferation, stemness, EMT and migration in recipient GES-1 cells, at least partly through activation of the Wnt/beta-catenin pathway (beta-catenin and c-Myc). |
| Confidence score: |
0.7571 |