| Expression pattern: |
UP |
| Associated gene: |
CD36 |
| Associated microRNA: |
miR-1254 |
| Biological function: |
Promotes proliferation, migration, invasion, and tumorigenesis of cervical cancer cells while inhibiting apoptosis. |
| Molecular mechanism: |
circ_ASH1L acts as a miR-1254 sponge to upregulate CD36 expression, thereby promoting malignant progression of cervical cancer. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Elevated circ_ASH1L expression was significantly associated with FIGO III + IV stage, low histological differentiation, and high levels of squamous cell carcinoma antigen; circ_ASH1L was proposed as a promising therapeutic target for CC treatment. |
| Description: |
circ_ASH1L is up-regulated in cervical cancer tissues and cell lines and shows oncogenic activity. It promotes proliferation, migration, invasion, and tumorigenesis while suppressing apoptosis by sponging miR-1254 and increasing CD36 expression. Its elevated expression is associated with advanced FIGO stage, low histological differentiation, and high SCC antigen levels, suggesting therapeutic relevance. |
| Confidence score: |
0.7898 |